ZINC DOPED COBALT FERRITES FOR ENHANCED MAGNETIC HYPERTHERMIA PERFORMANCE

Hafiz Safdar Ali; Muhammad Arslan; Aqsa Saleem; Kanwal Akhtar; Ayesha Younus; Yasir Javed

doi:10.71146/kjmr888

Authors

Hafiz Safdar Ali Faculty of Sciences, The Superior University, Lahore, Pakistan. Author
Muhammad Arslan Faculty of Sciences, The Superior University, Lahore, Pakistan. Author
Aqsa Saleem Faculty of Sciences, The Superior University, Lahore, Pakistan. Author
Kanwal Akhtar Department of Physics, Government College Women University, Faisalabad, Pakistan. Author
Ayesha Younus Department of Physics, Government College Women University, Faisalabad, Pakistan. Author
Yasir Javed Department of Physics, University of Agriculture, Faisalabad, Pakistan. Author

DOI:

https://doi.org/10.71146/kjmr888

Keywords:

Zn-doped CoFe₂O₄, Magnetic hyperthermia, Nanoparticles, Saturation magnetization, Specific loss power, Cancer therapy

Abstract

Overview of the synthesis, structural characterization, and magnetic hyperthermia performance of Zn-CoFe₂O₄ nanoparticles as a future candidate for biomedical applications. Hydrothermal method was used to prepare the nanoparticles with Zn substitution levels from 0.0 until 0.7. The single-phase spinel ferrite structures formation was confirmed by X-ray diffraction analysis. The inclusion of zinc modified the crystal structure of cobalt ferrite affecting fundamental magnetic characteristics including saturation magnetization, coercivity, and specific loss power (SLP). The particle with x = 0.2 exhibited the best magnetic hyperthermia performance among all compositions, owing to its strongest heating capability in external and alternating magnetic fields since it reached new maxima both for specific power losses (SLP) and intrinsic loss power (ILP). Therefore, it is concluded that the Zn-doped CoFe₂O₄ nanoparticles may represent ideal candidates for application on magnetic hyperthermia in anti-cancer treatment by generating effective cure temperatures with localized tumor ablation Zn-doped CoFe2O4f about 42–45 °C. The results show that zinc doping is an effective approach to tailoring the magnetic behavior of cobalt ferrite NPs for medical hyperthermia applications. However, additional investigations into biocompatibility, surface functionalization and in vivo performance are necessary before clinical application can be approbated.

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