NANOSTRUCTURED ELECTROCHEMICAL PLATFORM FOR RAPID SALIVARY BIOMARKER DETECTION USING GRAPHENE GOLD MODIFIED ELECTRODE
DOI:
https://doi.org/10.71146/kjmr885Keywords:
electrochemical biosensor, salivary biomarker detection, graphene–gold nanoparticle composite, nanostructured glassy carbon electrode, biosensing platform, noninvasive diagnostics, point-of-care monitoringAbstract
A nanostructured electrochemical sensing platform was engineered for fast and sensitive quantification of salivary biomarkers, enabling noninvasive approaches to disease diagnosis. The device was constructed by modifying a glassy carbon electrode with a graphene–gold nanoparticle (GNP) composite, which enhanced surface conductivity and accelerated electron transfer. Electrochemical and morphological characterization using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM) verified successful electrode functionalization and uniform nanocomposite coverage. The fabricated sensor exhibited high sensitivity and selectivity toward glucose and cortisol in saliva, achieving detection limits in the micromolar range. In addition, the system demonstrated excellent reproducibility and operational stability when evaluated with human saliva samples. Overall, this nanostructured electrochemical interface represents a promising, low-cost, and portable platform for rapid salivary diagnostics, well-suited to point-of-care health monitoring applications.
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Copyright (c) 2026 Mudassir Hussain, Anaya Fatima, Muniba BiBi, Sana Shamim, Said Jamal (Author)
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